Reddit-Benutzer berichten von GLP-1-Nebenwirkungen, die in klinischen Studien nicht erfasst wurden – eine Analyse von über 400.000 Beiträgen von Personen, die GLP-1 einnehmen, ergab Erwähnungen von unregelmäßigen Perioden, Müdigkeit, Schüttelfrost und Hitzewallungen.
https://www.everydayhealth.com/weight-management/reddit-users-reporting-glp-1-side-effects/
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Reddit Users Are Reporting GLP-1 Side Effects Not Captured in Clinical Trials
A University of Pennsylvania analysis of over 400,000 posts from people taking GLP-1s found mentions of irregular periods, fatigue, chills, and hot flashes.
A large-scale analysis of social media posts is offering a fresh look at what people say they’re experiencing in real life while taking a GLP-1 for diabetes or obesity.
Using artificial intelligence to scan more than 400,000 Reddit posts, researchers from the University of Pennsylvania documented numerous reports of possible GLP-1 side effects that may be underrecognized in clinical trials — including menstrual changes, fatigue, and temperature sensitivities.[1]
For those interested, here’s the link to the peer reviewed journal article:
https://www.nature.com/articles/s44360-026-00108-y
Does this mean research on GLP-1 could lead to better understanding of the physiology of menopause?
Sounds like symptoms of malnutrition which GLP-1s can cause when you aren’t eating enough..
Is it known if this can be attributed to GLP-1 vs natural cycles? Obviously a lot of women in the peri-menopausal and menopausal age demographics use GLP-1, so could that account for those effects?
Fascinating method of study, but I can’t help but think that without being able to adjust for pre-existing conditions etc this becomes extremely difficult to glean usable data from.
For all we know, those with delayed period changes could all have diagnosed/undiagnosed endometriosis that the GLP-1s interact with. It could also be the case that any set of 400,000 patients with no diagnosed medical conditions would self report this level of extra unexplained symptoms. This does seem like a nice stepping stone for other research though.
Are you telling me that cutting your daily vitamin and mineral intake and losing weight dramatically is bad for your hormone levels and body functionality?
*surprise pikachu*
It made my skin so sensitive it was wild. Felt like a permanent sunburn
Honestly the worst side effect for me is extreme food aversions. Especially for a few days after taking my Mounjaro. I pretty much stick to chicken nowadays – the smell of other meats raw or cooking is pretty awful.
I eat a pretty limited diet because those are the only foods I’m interested in nowadays.
Sounds like aging and menopause.
I’m on GLP-1 and I’ve been dealing with patular eustachian tube dysfunction in my ear. (Too much fat is removed around the eustachian tube which destabilizes it and prevents it from closing) My ENT said she’s noticed a serious increase in an otherwise very rare condition in GLP patients.
It is usually caused by unhealthily rapid, massive weight loss — but she’s been seeing it in GLP patients with moderate weight loss over a healthy period of time.
She theorized that GLP meds change *where* weightloss occurs, so even healthy, moderate weight loss can cause this. But it’s not mentioned anywhere in the literature, and so far no studies have been done.
I’ve also just had my gallbladder removed since the GLP slowed down my bile production so much that stones started forming and it got infected.
All in all I think it’s worth it, but my body is taking a beating.
Not eating as much food leads to your body’s hormones being out of wack and irregular periods? That’s the most shocking thing I’ve heard all day!
The irregular periods needs to be investigated. And NO it is not from the weight loss or nutritional issues.
I experienced period side effects pretty much immediately from the first shot.
People getting pregnant when they are NOT on oral BC but with an IUD or Implant. Women coming out of menopause.
These effects need to be investigated as they are not reported anywhere yet Women are being very vocal about it and being dismissed because „oh it’s just the estrogen in the fat you are losing“ No it’s not.
Throw in impotence for zepbound. Which is bizarre since I haven’t read about it anywhere else. But woomp there it wasn’t.
Experts say the findings should be interpreted cautiously because the data is anonymous, unverified, and doesn’t include a comparison group
I tend to agree. There’s some pretty massive selection biases. A massive amount of serial killers had carrots quite recently and all that.
How many of these were people who started out obese? How many under medical supervision? How many *needed* to lose weight to be healthy rather than skinny? How many were hallucinations?
Is this how we do science now? Point an AI at a social media site and ask it to look for people with medical problems?