Hauterkrankungen wie Psoriasis treten im Laufe des Lebens häufig an den gleichen Stellen auf. In einer neuen Studie an Mäusen zeigten Forscher, wie Hautzellen bei jeder Regeneration Muster der Genexpression erben.
https://www.scientificamerican.com/article/why-your-psoriasis-flares-up-in-the-same-spots/
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>Skin remembers. That scar above your eye from when you fell at age 6. That freckle from the summer you turned 13. Our skin is a repository of moments from our lives, and now scientists have found it really does remember. For people with inflammatory skin conditions such as psoriasis, the skin’s memory manifests in flare-ups in the same spots over and over. And now scientists think they know precisely why this happens.
>In a new [study](https://www.science.org/doi/10.1126/science.adz6830) in mice published on Thursday in Science, researchers showed how skin cells inherit patterns of gene expression every time they regenerate. The team found not only that successive generations of skin cells maintain the memory of their DNA’s structure but also that the cells inherit chemical modifications to the DNA called epigenetic marks, which can turn on or off, or turn certain genes up and down in a process called gene expression.
>“People knew that stem cells had the ability to change their behavior and remember, but they didn’t know if it was through this epigenetic mechanism,” says Shruti Naik, an immunologist at the Icahn School of Medicine at Mount Sinai, who has previously worked with the study’s senior author, Elaine Fuchs, but was not involved in the new research. “And I think what this paper does is definitively demonstrate that it’s through marking of DNA … that it allows that stem cell to now behave differently moving forward.”
Had a massive eczema flare-up over much of my body years ago during an extremely stressful time of my life. Got successful treatment and it essentially went away.
Since then, I experience two specific mini-flare-ups, one on my chest, and one on the edge of my right hand, almost constantly. Not even enough to warrant treatment, just enough to say “hi” periodically.
I’m going to have to read this after work. I wonder if this is a mechanism of aging. What happens if you disrupt or alter the pattern of inheritance? Really exciting concept!
Left eyelid, only in the winter. Obnoxious.
When I was in my 20s I had a huge spot on my ankle that persisted for more than a year. GP diagnosed as eczema, and treatments made no difference. She told me I was just scratching it too much.
Got a second opinion. She took one look and said psoriasis and prescribed a steroid cream. Went away in a couple weeks and hasn’t come back in close to 20 years. First GP went away too because f that.
Noooo I just got it in somewhere unfortunate, like extremely. I hope this isn’t true or at least for 100% of areas.
Does that mean we could have targeted therapy for those areas? The effect of psoriasis and eczema on well-being is often understated