Implantierbare „lebende Apotheke“: Ein winziges Gerät, implantierbar und aus Zellen hergestellt, produziert eine Kombination verschiedener Medikamente, kann mehrere Wochen lang ununterbrochen im Körper wirken und möglicherweise bei der Behandlung chronischer Krankheiten helfen

>A multi-institutional team of scientists, co-led by Northwestern University, has taken a crucial step toward implantable “living pharmacies” — tiny devices containing engineered cells that continuously produce medicines inside the body.
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>In a new study, the team engineered cells to simultaneously produce three different biologics — an anti-HIV antibody, a GLP-1-like peptide used to treat type 2 diabetes and leptin, a hormone that regulates appetite and metabolism. When implanted under the skin of a small animal model, the device kept drug-producing cells alive and stably delivered all three therapies at once.
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>Called HOBIT (short for hybrid oxygenation bioelectronics system for implanted therapy), the new system integrates the engineered cells with oxygen-producing bioelectronics. Roughly the size of a folded stick of gum, the design shields cells from the body’s immune system while also providing cells with oxygen and nutrients to keep them alive and producing biologic drugs for several weeks.
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>With more work, living pharmacies hold the potential to treat chronic conditions with a single, long-lasting therapy — bypassing the need for patients to carry, inject or remember to take medications.

[Design of a wireless, fully implantable platform for in-situ oxygenation of encapsulated cell therapies: Device](https://www.cell.com/device/abstract/S2666-9986(26)00058-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS266699862600058X%3Fshowall%3Dtrue)