Psilocybin ist möglicherweise nicht der psychoaktivste Inhaltsstoff in Zauberpilzen. Wissenschaftler fanden Hinweise darauf, dass mehrere Nebenverbindungen in diesen Pilzen zusammenarbeiten, um mit Gehirnrezeptoren zu interagieren, was möglicherweise erklärt, warum natürliche Extrakte oft andere Wirkungen hervorrufen als synthetische Versionen.
Psilocybin might not be the most psychoactive ingredient in magic mushrooms, new research suggests
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Psilocybin might not be the most psychoactive ingredient in magic mushrooms, new research suggests
A new study published in Scientific Reports suggests that the therapeutic effects of psychedelic mushrooms likely rely on a complex interplay of multiple chemical compounds rather than just a single active ingredient. Scientists found evidence that several minor compounds in these mushrooms work together to interact with brain receptors, potentially explaining why natural extracts often produce different effects than synthetic versions.
https://www.nature.com/articles/s41598-026-39483-7
FYI its extremely easy to grow cubensis mushrooms at home
Only stumbling block is contamination. But an air purifier drastically reduces the chances of losing mushroom spawn to mold.
[https://en.wikipedia.org/wiki/Entourage_effect](https://en.wikipedia.org/wiki/Entourage_effect)
[https://en.wikipedia.org/wiki/Psilocybin_mushroom#Composition](https://en.wikipedia.org/wiki/Psilocybin_mushroom#Composition)
Polar small molecules are difficult to quantify.
I’m glad they did this study.
This was sort of known anecdotally for imo decades now though. Everybody knows isolated psilocybin, or thc, or mescaline, is different in effects than a plant. extract.
I am the only one that assumes that to be the default assumption when working with any crude extracts until proven otherwise?
I had a real big heated discussion with my supervisor once when I assumed some expected results were due to the quick and dirty one pot approach even when the incubation times were slow. Yeah, it is on ice, but there are processes that are active on ice. Turns out time on ice after lysis increased the artefacts, and later in vivo experiments didn’t yield the same results. 6 months of work just because my prof. Smelled a major publication from an obvious experimental flaw.
This is the same, crude extract (let it be chromatography fractions) vs isolated molecule. You don’t need to be an expert in omics or system biology to be cautious with unaccounted factors.
Yeah, I’ve wondered about that now and then. Synthetic chemicals like 4-AcO-DMT are pretty close and apparently break down rapidly to psilocin in the bloodstream, but there’s a different overall feel to them.
This of course doesn’t mean that mushrooms were better; just that the experience is different. Synthetic forms of psilocin may very well be equally effective in e.g. psychedelic-assisted mental health treatments. I would imagine that part of the different feel comes from digestive effects and some of the psychoactives in these mushrooms are more-so affecting the paranervous system. They can e.g. increase or decrease blood pressure; those effects can be felt sure, but aren’t necessarily positive.