Patienten mit einer schweren depressiven Störung haben gemeinsame Immunanomalien mit entzündlichen Hauterkrankungen, insbesondere mit dem Immunpfad, der an der atopischen Dermatitis beteiligt ist. Da diese Hauterkrankungen behandelbar sind, legen die Ergebnisse neue Therapiemöglichkeiten auch für psychiatrische Erkrankungen nahe.
https://www.mountsinai.org/about/newsroom/2026/major-depressive-disorder-shares-immune-abnormalities-and-potential-therapeutic-targets-with-inflammatory-skin-diseases-according-to-new-study
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A team of leading clinical research scientists from the Departments of Psychiatry and Dermatology at the Icahn School of Medicine at Mount Sinai has found that the serum of **patients with major depressive disorder shares immune abnormalities with inflammatory skin diseases, most notably the common Th2 immune pathway that is implicated in atopic dermatitis. Because these skin diseases are treatable, the findings suggest new therapeutic possibilities for psychiatric illness as well**.
The study findings, published February 11 in Molecular Psychiatry, underscore the potential role of the Th2 axis in major depressive disorder and highlight the potential of targeting this specific immune pathway that involves interleukin-4 receptor alpha, a cell receptor known to play a key role in regulating inflammation, as a disease-modifying treatment for this psychiatric disorder. Furthermore, the back-translational drug repurposing strategy employed in this study may offer a new approach to identifying immunomodulatory drugs in psychiatry.
Major depressive disorder is a neuropsychiatric disorder that affects millions of people and often does not respond to current treatments. There is increasing evidence of a close interaction between the brain and immune system that contributes to the pathophysiology of stress-related disorders, including major depressive disorder.
For those interested, here’s the link to the peer reviewed journal article:
https://www.nature.com/articles/s41380-025-03383-5
Lines up with how a lot of MDD may be caused by entirely physiological factors like neuroinflammation, hormonal anomalies, vitamin deficiencies, etc,. It’s why treatment for depression shouldn’t just be palliative, but investigated, as solving the underlying condition is going to be better in the long run.
huh, ive been diagnosed both with bipolar & have exczema
This reminds me of a women who had very severe catatonic schizophrenia for ~20 years. Eventually (while she was basically unresponsive) a doctor figured out she had Lupus, and started treating that. She woke up and was fine, back to her old self. She never had schizophrenia in the first place!
https://www.healio.com/news/rheumatology/20230921/dont-give-up-catatonic-woman-wakes-up-after-20-years-following-treatment-for-lupus
It makes you wonder, how many completely separate disorders do we mistakenly think are the same thing? How many other “schizophrenic” people actually have something autoimmune causing it?
So I’ve had really bad eczema and dermatitis, got put on Rinvoq and both of those are gone and I’m actually less depressed (though it’s a gradual veil lifting). Maybe a (awesome) coincidence but it’s been a great outcome so far
I have major depressive disorder and eczema. Never would’ve guessed there’d be any sort of connection. I wonder how many people out there have a combination of atopic dermatitis and mental health issues?
How is it concluded that a psychological illness can be treated based on a physiological illness being treatable. It’s not like the dermatitis causes the major depression