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    Eingenommenes Mikro- und Nanoplastik kann die Neurodegeneration fördern, indem es die Mikrobiota-Darm-Hirn-Achse stört und systemische Entzündungen, oxidativen Stress und epigenetische Dysregulation verstärkt, so eine Übersicht


    Eingenommenes Mikro- und Nanoplastik kann die Neurodegeneration fördern, indem es die Mikrobiota-Darm-Hirn-Achse stört und systemische Entzündungen, oxidativen Stress und epigenetische Dysregulation verstärkt, so eine Übersicht

    https://www.mdpi.com/2073-4425/17/2/151

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    9 Kommentare

    1. sometimeshiny on

      ### [Nuclear and Mitochondrial Epigenetic Mechanisms Underlying Neurodegeneration and Gut–Brain Axis Dysregulation Induced by Micro- and Nanoplastics (2026) – Pavlovic et al.](https://doi.org/10.3390/genes17020151)

      | Abstract |
      |—|
      | The increasing and global distribution of microplastics and nanoplastics (MPs/NPs) in the environment has led to concern about their potential influence on human health, especially on the gastrointestinal tract, as well as the brain. MPs/NPs could traverse epithelial and endothelial barriers, disrupt the gut microbiota, and perturb the microbiota–gut–brain axis, leading to systemic inflammation and possibly extending neurodegenerative processes. Experimental models now demonstrate that MPs/NPs reprogram nuclear and mitochondrial epigenetics—DNA methylation, histone modifications, non-coding RNAs, and mitochondrial DNA regulation—in gut, immune, and neural cells with downstream effects on synaptic function, neuronal survival, and protein aggregation. This mechanistic narrative review integrates preclinical and emerging human evidence of how MPs/NPs compromise intestinal barrier integrity, modulate gut microbiota composition, affect the blood–brain barrier, and converge on oxidative stress, neuroinflammatory signaling, and cell death pathways within the central nervous system across key neurodegenerative diseases. Overall, the review offers an integrated model in which environmental exposure to chronic MPs/NPs disrupts the microbiota–gut–brain axis and drives concurrent nuclear and mitochondrial epigenetic remodeling, lowering the threshold for neurodegeneration in susceptible individuals, while outlining candidate mechanistic readouts that require exposure-specific validation in human-relevant models and longitudinal cohorts. |

    3. GerbilPortal on

      How do we help avoid this? Like what’s the 80/20 that we can impact?

      I did some research and have switched out:
      1. No more plastic cutting boards.
      2. No more re-heating food in cheap plastic.

      3. Uhhhh that’s as far as I got.

    5. aledba on

      Did we honestly not know this already because I feel like I definitely knew this once we were told about microplastics?

    6. Chr1sm4nic on

      Microplastics are honestly pretty scary, there’s little one can do to FULLY avoid them, especially when you’re barely getting by as is. and we know little about the long term effects but studies show an increased amount of Microplastics in the brains of dementia patients. „The amount of microplastics in the human brain appears to be increasing over time: Concentrations rose by roughly 50 percent between 2016 and 2024“ source: UNM Health.

    8. snugglelamping on

      I’m quite worried I’m dealing with this or a hidden source of contaminants as I’ve been having a sinus inflammation problem for close to 6 months now. The worst part is it’s so hard to tell if I’m down with sickness or if my immune system has degraded over time.

    9. UWO_Throw_Away on

      Oh great; getting older and my guts have been incredibly uncooperative lately

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