Orale Bakterien stehen im Zusammenhang mit dem Schweregrad der Behinderung bei Multipler Sklerose (MS). Erkenntnisse bringen Fusobacterium nucleatum mit der Schwere der MS-Erkrankung in Verbindung. Es gibt zunehmend Hinweise darauf, dass die schwere Zahnfleischerkrankung Parodontitis durch chronische Entzündungen zu Störungen des Zentralnervensystems beitragen kann.

**Oral bacterium tied to disability severity in multiple sclerosis**

**Findings connect Fusobacterium nucleatum with multiple sclerosis disease severity**

Researchers found that multiple sclerosis (MS) patients exhibiting moderate to severe disability tend to have higher levels of Fusobacterium nucleatum, a common gum bacterium. The link appeared only in MS and not in related autoimmune diseases, suggesting that oral bacteria may possibly influence how severe MS becomes. (Pexels)

**Increasing evidence suggests that the severe gum disease, periodontitis, may contribute to central nervous system disorders through chronic inflammation**. However, its role in multiple sclerosis, a chronic autoimmune disease of the central nervous system, has been unclear. A research team has conducted a study with findings that suggest a potential association between the relative abundance of Fusobacterium nucleatum (F. nucleatum), a bacterium found in the mouth, and disease severity in multiple sclerosis (MS) patients.

Their research is published in the journal Scientific Reports on November 3, 2025.

Multiple sclerosis is a central inflammatory demyelinating disease that targets the myelin sheath, the protective layer that wraps around some nerve cells. While the specific cause of multiple sclerosis remains unknown, viral infections, smoking, vitamin deficiencies, and genetic predispositions are thought to be possible contributing factors.

The prevalence of multiple sclerosis has been steadily increasing in Japan since the 1980s. This rapid increase might be influenced by environmental changes. Scientists have extensively studied alterations in the gut microbiome related to this. Recent attention has expanded to include the possible role of oral microbiota, alongside gut microbiota, in central nervous system diseases.

Periodontal disease is a chronic bacterial infection that triggers persistent inflammation in periodontal tissues. It ultimately destroys the connective tissues and alveolar bone and result in tooth loss. Periodontal disease is common, with a global prevalence of 40 to 60 percent. Researchers know that it increases the risk of diseases like atherosclerosis, diabetes, and rheumatoid arthritis.

For those interested, here’s the link to the peer reviewed journal article:

https://www.nature.com/articles/s41598-025-22266-x

Want to know what helps gum disease more than dentists will admit? The very same thing that helps prevent scurvy. Vitamin C