Eine Rezension zeigt, dass Psychedelika bei Zwangsstörungen vielversprechend sind, Cannabis hingegen nicht. Cannabinoide aktivieren CB1-Rezeptoren, die Zwänge und Ängste regulieren, aber keine dauerhafte Linderung bieten. Psilocybin reduziert die Konnektivität im Standardmodus-Netzwerk, das an selbstreferenziellem Denken und Grübeln beteiligt ist.

I’ve linked to the news release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:

https://www.sciencedirect.com/science/article/pii/S0022395625007253

From the linked article:

**Psychedelic treatments show promise for OCD while cannabis doesn’t, review finds**

Psychiatry professor theorizes that the difference is related to how the substances interact with areas of the brain

A recent review of alternative treatments for obsessive compulsive disorder (OCD) indicates that psychedelic treatments show promise for the disorder while cannabis does not.

Dr Michael Van Ameringen, a psychiatry professor at McMaster University in Ontario, Canada and lead author of the review published in the Journal of Psychiatric Research, said that 40-60 % of OCD patients get either partial or no relief with available treatments, including SSRIs and exposure and response prevention therapy.

While psychedelics and cannabinoids have become part of the conversation surrounding OCD – a disorder characterized by intrusive, obsessive thoughts and/or compulsive behaviors – there is a much larger body of published evidence on the efficacy of these substances for more common conditions, like depression and anxiety.

Upon compiling available evidence, Van Ameringen and his team found “stronger signals” for the efficacy of psychedelics, specifically psilocybin (the psychoactive component of “magic mushrooms,”) than for cannabinoids like THC and CBD.

Van Ameringen theorizes that the difference is related to how these substances interact with areas of the brain related to OCD. **While cannabinoids activate the brain’s CB1 receptors, which regulate symptoms like compulsions and anxiety, available evidence shows they don’t offer lasting relief from OCD symptoms.**

**Psilocybin, on the other hand, can reduce connectivity in the brain’s default mode network, which “essentially is involved in self referential thinking and rumination. The default mode network is really activated in OCD**”, he says.