Eine neue Studie der Stanford University zeigt einen direkten Zusammenhang zwischen mRNA-COVID-19-Impfstoffen und Myokarditis und erklärt den Wirkmechanismus

Copying and pasting this from the same article for the vaccine skeptics:

“But COVID’s worse,” he added. A case of COVID-19 is about 10 times as likely to induce myocarditis as an mRNA-based COVID-19 vaccination, Wu said. That’s in addition to all the other trouble it causes.

The title says **can** cause and they have ideas about how to address it.

Also:

>Vaccine-associated myocarditis occurs in about one in every 140,000 vaccinees after a first dose and rises to one in 32,000 after a second dose.

This a very high impact factor publications. The study design is very well done.

The actual publication

„Messenger RNA (mRNA) vaccines against SARS-CoV-2 are highly effective and were instrumental in curbing the COVID-19 pandemic. However, rare cases of noninfective myocarditis, particularly in young males and typically after the second dose, have been observed. Here, we explore the mediators of this myocarditis to better understand and to enhance the safety of future mRNA vaccines. Through analysis of human plasma data and in vitro experiments with human macrophages and T cells, we identified increased C-X-C motif chemokine ligand 10 (CXCL10) and interferon-γ (IFN-γ) after exposure to BNT162b2 (Pfizer) or mRNA-1273 (Moderna). Neutralization of CXCL10 and IFN-γ during the second dose (21 days after the first dose) reduced vaccine-induced cardiac injury in mice. Neutralization also reduced cardiac stress markers such as the release of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and expression of inflammatory genes in human induced pluripotent stem cell (iPSC)–derived cardiac spheroids. When exposed to these cytokines in vitro, human iPSC-derived cardiomyocytes (iPSC-CMs) exhibited impaired contractility, arrhythmogenicity, and proinflammatory gene expression patterns. Genistein, a phytoestrogen implicated in reducing cardiovascular inflammation, mitigated these effects in iPSC-CMs. In mice exposed to these cytokines or receiving BNT162b2 vaccination, genistein treatment reduced cardiac injury markers and attenuated infiltration of neutrophils and macrophages into the heart. These findings implicate CXCL10–IFN-γ signaling as a contributor to myocardial injury in experimental models of mRNA vaccination and indicate that pharmacologic modulation, such as with genistein, may mitigate cytokine-driven injury.“

What if you get the vaccine and also get COVID?

i’d rather risk that than covid crossing the blood brain barrier in me AGAIN. i literally feel dumber after catching it.

there is ALWAYS some measure of risk associated with a medication, a vaccine, a treatment, etc.

i’d rather do chemo than die of cancer. i consider the choice here for the covid vaccine similarly.

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Purposely using this title is peak misinformation

What a stupid title, so many people only read the titles and will not understand how much worse it is when you actually have the disease itself.

I am expecting… so many damn shares and posts of this missing the point entirely.

It’s great that it’s now got solid scientific proof it’s safe. It’s extremely unethical that people were getting fired for not taking it when your average vaccine has 7 years of long term clinical trials while this had a couple months of short term clinical trials and no FDA approval outside of emergency use authorization.

Vaccines work, and they work because of long term clinical trials proving their efficacy and safety. If you’re pro science you would agree with what I’m saying.

You know what’s way worse than covid? Whooping caugh. You need to get a vaccine every 10 year for it to be effective. You DO NOT want to get that disease trust me. Vaccines save lives.

Oh criminey, the MAGAts are gonna come out of the woodwork on this one, completely missing the science and just reading the headline.

Researchers have been pointing to unintended intravascular exposure as a potential mechanism for years. This is not a fringe idea and it is not new.

mRNA vaccines are intended to remain largely localized after intramuscular injection. If lipid nanoparticles enter the bloodstream instead, antigen expression becomes systemic. That is exactly the condition that would be expected to trigger a strong innate immune response, including macrophage activation, CXCL10 release, IFN-γ–skewed T-cell signaling, and immune cell recruitment into highly perfused tissues like the myocardium. The Stanford paper lays out this downstream immune cascade in detail. It does not explain what initiates it, but the biology lines up cleanly with intravascular exposure.

At the same time, routine aspiration of the needle was quietly removed from vaccination protocols, even though the deltoid is not avascular and aspiration is the simplest available safeguard against direct vascular delivery. Removing that step necessarily increases the rate of accidental IV injection. There is no plausible argument that it decreases it.

This study strongly supports the long-standing IV hypothesis. It fills in the missing middle of the causal chain. Systemic exposure leads to the immune signaling described here, and the decision to stop aspirating needles made that exposure more likely for no clear medical benefit.

At any rate, *always* ask the practitioner to aspirate the needle when receiving an IM injection. It literally takes two seconds and there’s no reason not to do it.

Can someone ELI5 the mechanism of action from the study?