Wissenschaftler entdecken Schlüsselfaktor für behandlungsresistenten Krebs: „Wissenschaftler der UC San Diego entdecken Enzym, das für die Verwirrung von Krebsgenomen verantwortlich ist; Die Ergebnisse könnten neue Behandlungen für die aggressivsten Krebsarten ermöglichen. »
https://today.ucsd.edu/story/scientists-uncover-key-driver-of-treatment-resistant-cancer
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« This discovery finally reveals the molecular ‘spark’ that ignites one of the most aggressive forms of genome rearrangement in cancer. By finding what breaks the chromosome in the first place, we now have a new and actionable point of intervention for slowing cancer evolution. »
Reference: Ksenia Krupina et al., Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes. Science 390, 1156-1163 (2025). DOI: 10.1126/science.ado0977. https://www.science.org/doi/10.1126/science.ado0977