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    1. wiredmagazine on

      Amy Lindberg spent 26 years in the Navy and she still walked like it—with intention, like her chin had some place to be. But around 2017, her right foot stopped following orders. Lindberg and her husband Brad were five years into their retirement. After moving 10 times for Uncle Sam, they’d bought their dream house near the North Carolina coast. They had a backyard that spilled out onto wetlands. From the kitchen, you could see cranes hunting. They kept bees and played pickleball and watched their children grow.

      But now Lindberg’s right foot was out of rhythm. She worked hard to ignore it, but she couldn’t disregard the tremors. And she’d started to misplace words and thoughts, especially when she got excited. Was this normal? She was 57, fit and clean-living. Could the culprit be menopause?

      The diagnosis took all of five minutes. Lindberg had Parkinson’s disease, the neurologist said, with all the classic symptoms. PD—as the scientists she would meet call it—is a neurological disorder, and a life sentence. Sufferers gradually lose control of their muscles, their bowels, their esophagus. Doctors told Lindberg that there was no way to know what had caused it.

      The daughter of a sailor, Lindberg had built her life around the military. She was commissioned in the Navy out of college and became an officer at 23. Her first posting was to Marine Corps Base Camp Lejeune in North Carolina, a city-sized training hub that supports more than 60,000 sailors and marines. There were murmurs even then—whispers of weird cancers and stillbirths. The bachelor officers’ quarters were on a grassy thumb of shoreline called Paradise Point, where the New River meets the Atlantic.

      She never suspected the water.

      In a blockbuster study, epidemiologist Sam Goldman compared the health records of two Marine bases, Camp Pendleton and Camp Lejeune. Lejeune has contaminated drinking water, Pendleton does not. When Goldman compared both the populations, the results were shocking.

      Read the full story: [https://www.wired.com/story/scientists-thought-parkinsons-was-in-our-genes-it-might-be-in-the-water/](https://www.wired.com/story/scientists-thought-parkinsons-was-in-our-genes-it-might-be-in-the-water/)

    2. LieutenantBrainz on

      To be clear, while there may be many unknown causative factors, there are established associated genes with idiopathic Parkinson’s disease.

    3. I guessed Camp Lejeune. Maybe in the water? Thousands of vets and their families say otherwise, no maybe.

    4. Over the summer of 1982, Langston found five more “frozen addicts” across the Bay Area. Through gumshoe detective work, he discovered they had all injected a batch of what they believed to be a designer drug called MPPP, cooked in a Morgan Hill basement. But the chemistry had gone awry. Instead of 1-methyl-4-phenyl-4-propionoxypiperidine, a potent opioid with morphine-like effects, the dime-bag chemist had accidentally made 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, or MPTP, a pharmacological slipup that would rewrite neurology textbooks.

      When Langston and colleagues secured a batch of MPTP and tested it on primates, they knew they had uncorked a revolution. “Any neurologist could see these monkeys and immediately know that’s Parkinson’s,” Langston says—which was especially compelling, since monkeys do not get Parkinson’s in the wild. In a first, Langston showed that MPTP killed the dopamine-producing neurons in monkeys’ substantia nigra. The discovery made him the most famous Parkinson’s researcher in the country and, Langston wrote at the time, promised to “turn the entire field of Parkinson’s disease upside down.” Parkinson’s, it appeared, could be caused by a chemical.

      yah that is pretty interesting.

    5. SeriousAsPie on

      # Scientists Thought Parkinson’s Was in Our Genes. It Might Be in the Water

      New ideas about chronic illness could revolutionize treatment, if we take the research seriously.

      Amy Lindberg spent 26 years in the Navy and she still walked like it—with intention, like her chin had someplace to be. But around 2017, her right foot stopped following orders. Lindberg and her husband Brad were five years into their retirement. After moving 10 times for Uncle Sam, they’d bought their dream house near the North Carolina coast. They had a backyard that spilled out onto wetlands. From the kitchen, you could see cranes hunting. They kept bees and played pickleball and watched their children grow.

      But now Lindberg’s right foot was out of rhythm. She worked hard to ignore it, but she couldn’t disregard the tremors. And she’d started to misplace words and thoughts, especially when she got excited. Was this normal? She was 57, fit and clean-living. Could the culprit be menopause?

      The diagnosis took all of five minutes. Lindberg had Parkinson’s disease, the neurologist said, with all the classic symptoms. PD—as the scientists she would meet call it—is a neurological disorder, and a life sentence. Sufferers gradually lose control of their muscles, their bowels, their esophagus. Doctors told Lindberg that there was no way to know what had caused it.

      The daughter of a sailor, Lindberg had built her life around the military. She was commissioned in the Navy out of college and became an officer at 23. Her first posting was to Marine Corps Base Camp Lejeune in North Carolina, a city-sized training hub that supports more than 60,000 sailors and marines. There were murmurs even then—whispers of weird cancers and stillbirths—but Lejeune was one of the prettier pieces of land in the Navy’s property portfolio. The bachelor officers’ quarters were on a grassy thumb of shoreline called Paradise Point, where the New River meets the Atlantic.

      “Lejeune was just picturesque,” Lindberg says. “We had a river right there, and the beach wasn’t far away, and you worked half a mile from where you lived.” She loved her job at the hospital and made lifelong friends. She met her husband—a photo on her desk shows a blond Lindberg beaming beneath her Navy cap while Brad smiles broadly in his dress blues. “It was really nice,” she says. “You’d never suspect the water.”

    6. BodybuilderLarge3904 on

      Ask me why my 2,4 ghz WiFi SSID is “do not drink the water”

    7. samuelazers on

      Most Parkinson’s cases are not clearly geneticly inherited. But i would be surprised if we didn’t already compare water quality to Parkinson’s incidence. IIRC pesticides and general toxins can cause it. So i guess filtering water is a good idea especially if they live near industrial or agricultural places

    8. This made me think of the medication Reglan. I have been given it when in the hospital for my Gastroparesis flares. Years ago I didn’t know what it was and only told it would stop the nausea and vomiting which I was desperate for. But shortly after getting it in my iv I had uncontrollable  spasms/tics, which I’d never experienced before. It felt mentally and physically exhausting to be so out of control. I was given it twice more in two other hospitals and the same happened but worse. I had told of my reaction but was still given the need,  told it was the best for those symptoms. 

      Now it’s listed as an allergy as my gastroenterologist has instructed me to do because the Parkinson’s like symptoms can be permanent. Despite that,  it was literally on my allergen bracelet in the ER, my first time back in the hospital for my stomach issues in years, a doctor was about to administer a shot of it into my iv. Luckily I stopped to ask what it was and she said „Reglan “ and that she had not noticed it listed under Allergen and still tried to sell it to me as the best to stop the nausea and vomiting. 

      I’m told it crossed the blood/brain barrier and that’s why can have the Parkinson’s like side effects. I had spasms and tics for days after being given in via iv, even though I’m told the symptoms shouldn’t last that long but also told in a small percentage of people the side effects linger and they’re the ones that the symptoms might remain in. 

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