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    1. „The GPR133 receptor appears tuned to both force and a partner molecule on neighboring cells. Inside the cell, the signal boosts cyclic AMP (cAMP), a small messenger that switches on enzymes, and which leads to downstream changes that favor bone formation.

      One of those changes touches beta-catenin, a protein that helps turn on bone building genes. The canonical Wnt pathway uses beta catenin to drive osteoblast programs.

      Multiple studies show how essential it is for bone maintenance. A comprehensive review details Wnt’s central role across development and repair.“

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