With a snip of a gene, doctors may one day permanently lower dangerously high cholesterol, possibly removing the need for medication, according to a new pilot study published Saturday in the New England Journal of Medicine.
The study was extremely small — only 15 patients with severe disease — and was meant to test the safety of a new medication delivered by CRISPR-Cas9, a biological sort of scissor which cuts a targeted gene to modify or turn it on or off.
Preliminary results, however, showed nearly a 50% reduction in low-density lipoprotein, or LDL, the “bad” cholesterol which plays a major role in heart disease — the No.1 killer of adults in the United States and worldwide.
Fun fact: Most people who end up hospitalized for conditions that are assumed to be caused/contributed to by high cholesterol, do not actually exceed „safe“ cholesterol levels.
If anything, this kind of intervention could have NEGATIVE health effects on people.
Ok_Imagination4806 on
I’m healthy but have always had very high ldl. I’m 42 and can bench my body weight 15 times and run a 7 min mile at 6 ft tall but my ldl is still 300. Wish I could get in this study. I hate taking statins.
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With a snip of a gene, doctors may one day permanently lower dangerously high cholesterol, possibly removing the need for medication, according to a new pilot study published Saturday in the New England Journal of Medicine.
The study was extremely small — only 15 patients with severe disease — and was meant to test the safety of a new medication delivered by CRISPR-Cas9, a biological sort of scissor which cuts a targeted gene to modify or turn it on or off.
Preliminary results, however, showed nearly a 50% reduction in low-density lipoprotein, or LDL, the “bad” cholesterol which plays a major role in heart disease — the No.1 killer of adults in the United States and worldwide.
Read more – [https://cnn.it/4qNc5sP](https://cnn.it/4qNc5sP)
That’s some very positive news.
Fun fact: Most people who end up hospitalized for conditions that are assumed to be caused/contributed to by high cholesterol, do not actually exceed „safe“ cholesterol levels.
[https://www.eurekalert.org/news-releases/583356](https://www.eurekalert.org/news-releases/583356)
If anything, this kind of intervention could have NEGATIVE health effects on people.
I’m healthy but have always had very high ldl. I’m 42 and can bench my body weight 15 times and run a 7 min mile at 6 ft tall but my ldl is still 300. Wish I could get in this study. I hate taking statins.