Demenz im Zusammenhang mit Problemen mit dem Abfallbeseitigungssystem des Gehirns: Eine beeinträchtigte Bewegung der Gehirn-Rückenmarks-Flüssigkeit (CSF) prognostizierte das Risiko einer Demenz im späteren Leben bei 40.000 Erwachsenen. Das glymphatische System dient dazu, Giftstoffe und Abfallstoffe auszuscheiden und so das Gehirn gesund zu halten.

I’ve linked to the press release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:

https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70699

From the linked article:

**Dementia linked to problems with brain’s waste clearance system**

Problems with the brain’s waste clearance system could underlie many cases of dementia and help explain why poor sleep patterns and cardiovascular risk factors such as high blood pressure increase the risk of dementia.

A study led by researchers at the University of Cambridge found that **impaired movement of cerebrospinal fluid (CSF) – the clear liquid that cushions and cleans the brain – predicted risk of dementia later in life among 40,000 adults** recruited to UK Biobank. Their findings are published today in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association and are being presented at the World Stroke Congress 2025 in Barcelona.

In the healthy brain, the so-called **glymphatic system serves to clear out toxins and waste materials, keeping the brain healthy**. Only discovered as recently as 2012, this system functions by flushing CSF through the brain along tiny channels around blood vessels known as perivascular spaces. It collects waste then drains out of the brain, helping keep it clean and healthy.

The glymphatic system is thought to be important in protecting against many of the common forms of dementia, which are often characterised by the build-up of toxic substances in the brain – for example, Alzheimer’s disease sees amyloid ‘plaques’ and tau ‘tangles accumulate in brain tissue.

That actually makes a lot of sense if the brain can’t flush out its own waste properly, stuff like plaque and toxins just build up over time. Kinda wild how it works like a cleaning system we never really think about.

the best way to combat this would be first and foremost hydration correct?

this might explain why fighters get such bad CTE cuz they cut so much water weight hours before fighting then incur brain damage then drink alchohol like a lunatic at the after parties.

hydration and sleep are needed for the brain.

I suspect this is probably a silly question, but I will ask it anyway just in case for the peanut gallery:

Can this be obviated with spinal taps? „Clearing“ the fluid and forcing the body to make more fresh?

Could this in any way tie in with Long Covid brainfog?

Feels like your brain is full of dust and you deal with very dementia-esque neuro issues.

Ties in pretty well with the effects of sleep on flushing out waste and lack of sleep tied to dementia.

I think this, sleep quality, sleep apnea and adhd are all related.

I think it was yesterday we got a breakthrough on schizophrenia and today its dementia. Very cool!