Laut einer Studie mit 63.433 Teilnehmern, die in den 1950er Jahren geboren wurden, ist eine eingeschränkte Zuckeraufnahme im frühen Leben (in den ersten 1000 Lebenstagen) mit einem geringeren Risiko für verschiedene Herzerkrankungen im Erwachsenenalter verbunden, darunter Herzinfarkt, Herzversagen und Schlaganfall

>Using the end of UK sugar rationing in September 1953 as a natural experiment, they drew on data from 63,433 UK Biobank participants (average age 55 years) born between October 1951 and March 1956 with no history of heart disease.
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>In total, the study included 40,063 participants exposed to sugar rationing and 23,370 who were not.
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>Linked health records were then used to track rates of cardiovascular disease (CVD), heart attack, heart failure, irregular heart rhythm (atrial fibrillation), stroke, and cardiovascular death, adjusting for a range of genetic, environmental, and lifestyle factors.
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>An external control group of non-UK born adults who did not experience sugar rationing or similar policy changes around 1953 were also assessed for more reliable comparisons.
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>The results show that longer exposure to sugar rationing was associated with progressively lower cardiovascular risks in adulthood, partly due to reduced risks of diabetes and high blood pressure.
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>Compared with people never exposed to rationing, those exposed in utero plus 1–2 years had a 20% reduced risk of CVD, as well as reduced risks of heart attack (25%), heart failure (26%), atrial fibrillation (24%), stroke (31%), and cardiovascular death (27%).
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>People exposed to rationing in utero and during early life also showed progressively longer delays (up to two and a half years) in the age of onset of cardiovascular outcomes compared with those not exposed to rationing.
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>Sugar rationing was also associated with small yet meaningful increases in healthy heart function compared with those never rationed.
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>The authors point out that during the rationing period, sugar allowances for everyone, including pregnant women and children, were limited to under 40 g per day – and no added sugars were permitted for infants under 2 years old – restrictions consistent with modern dietary recommendations.

[Exposure to sugar rationing in first 1000 days after conception and long term cardiovascular outcomes: natural experiment study | The BMJ](https://www.bmj.com/content/391/bmj-2024-083890)