Alzheimers umgekehrt bei Mäusen unter Durchbruchbehandlung
https://www.telegraph.co.uk/news/2025/10/07/alzheimers-reversed-in-mice-under-breakthrough-treatment/
Alzheimers umgekehrt bei Mäusen unter Durchbruchbehandlung
https://www.telegraph.co.uk/news/2025/10/07/alzheimers-reversed-in-mice-under-breakthrough-treatment/
8 Kommentare
***The Telegraph reports:***
Alzheimer’s disease has been reversed in mice in a breakthrough that offers hope that the disease may [one day be curable](https://www.telegraph.co.uk/news/2025/07/28/new-drug-could-halt-alzheimers-disease/).
Spanish and Chinese researchers have found a way to restore the function of the blood-brain barrier, so it can clear out the sticky amyloid beta plaques that stop brain cells from communicating.
The blood-brain barrier is a “gatekeeper” that surrounds the brain, controls what enters and exits, and keeps out toxic substances, while allowing harmful substances inside to be cleared out.
In [Alzheimer’s patients](https://www.telegraph.co.uk/health-fitness/conditions/dementia/alzheimers-questions-answered-by-dementia-specialist/), these gatekeeping systems become clogged and inefficient, so researchers created nanoparticles which “remind” the barrier how to work properly.
Nanoparticles are injected into the bloodstream, where they travel to the barrier, attach to it and stimulate natural mechanisms, so that the brain can access nutrients and clear out waste, restoring [healthy brain function](https://www.telegraph.co.uk/news/2025/07/31/alzheimers-wonder-drug-delays-disease-for-four-years/).
Researchers tested the therapy in mice genetically programmed to produce large amounts of amyloid beta, which leads to significant cognitive decline, mimicking Alzheimer’s.
**Read more:** [**https://www.telegraph.co.uk/news/2025/10/07/alzheimers-reversed-in-mice-under-breakthrough-treatment/**](https://www.telegraph.co.uk/news/2025/10/07/alzheimers-reversed-in-mice-under-breakthrough-treatment/)
Remember when this sub was for peer reviewed articles only, pepperidge me remembers :sad face
This sounds really promising for a lot of people if it passes further testing. I’m looking forward to seeing how this develops.
The amount of things that have been cured in mice is amazing
Alzheimer’s or a „mouse model of Alzheimer’s?“
But it’s not the same thing is it? I mean there are already some treatments avaliable that clean up the beta amyloid plaque and although syntoms actually improve, it doesn’t reverse damage.
The ugly truth is that neurodegenerative diseases are caused by more than one thing.
Hoping to be wrong with my take
I know someone working on their PhD in closely related study, right now. CRISPR modding antibodies to cross BBB.. they’re using gerbils rather than mice, but various dementia modes will yield to science soon. The drugs will need to be prescribed very early to get reversal of disease in humans though.
„Injection of nanoparticles “reminds” blood-brain barrier to work properly, allowing brain cells to communicate again“