Demenzgebundenes Protein niedriger bei Menschen, die eine heftige Übungsstudie melden, findet | Körperliche Aktivität und blutbasierte Biomarker der Neurodegeneration in der Gemeinde in Australiern aus der Insel (Inselstudie, die Alterung und neurodegenerative Erkrankung verbindet)

News article highlights:

>Now, a new study has found a link between exercise and a reduction in a protein in the blood, which is associated with dementia.
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>The recently published paper by the Wicking Dementia Research and Education Centre at the University of Tasmania has also found that the more vigorous the exercise, the more brain health is protected.
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>…
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>For the first time, scientists have been able to look at what impact reported levels of physical activity have on levels of a protein in the blood called serum glial fibrillary acidic protein or GFAP.
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>Wicking Centre director, Professor James Vickers, said GFAP was linked with brain inflammation.
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>“So it’s a good marker for general brain health,“ he said.
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>The reduction in the protein is even greater for participants who engage in more vigorous forms of exercise.
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>“Things like running or swimming, things that make you puff and pant,“ Dr Roccati said.
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>The association between vigorous exercise and a reduction in the GFAP protein was less strong in participants with the ApoE4 gene.
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>About 25 per cent of people carry one copy of ApoE4 and 2 to 3 per cent of people carry two copies.
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>ApoE4 is the strongest genetic risk factor for Alzheimer’s disease and dementia.
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>…
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>Dr Roccati said even though the reduction in the protein was not as strong for people with the gene, physical exercise was still important.
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>“You shouldn’t look at genes as determining your fate [you] should be like, ‚I’ve got this gene and now I am going to look at the best risk factors for me to address so I can reduce my risk of dementia over time‘,“ he said.
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>The new study adds to growing evidence that around 45 per cent of dementia cases could be prevented by addressing modifiable lifestyle and behavioural risk factors.

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Journal link: [Physical activity and blood-based biomarkers of neurodegeneration in community dwelling Australians from ISLAND (Island Study Linking Ageing and Neurodegenerative Disease)](https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.70166)

Abstract:

>Introduction
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>Physical activity, a key modifiable risk factor for dementia, has been associated with biomarkers of neurodegeneration in the central nervous system, but less is known regarding blood-based biomarkers.
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>Methods
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>A total of 739 cognitively healthy participants (aged 50–83 years) from ISLAND (Island Study Linking Ageing and Neurodegenerative Disease) completed a battery of online surveys. Self-reported physical activity was assessed based on daily metabolic equivalent, and a blood sample was analyzed for serum neurofilament light chain, serum glial fibrillary acidic protein (GFAP), plasma phosphorylated tau, and genotyped for apolipoprotein E (APOE) ε4.
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>Results
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>Higher self-reported physical activity was significantly associated with lower log-transformed concentrations of GFAP (pg/mL, β = −0.022, P = 0.009) in fully adjusted generalized linear regression models. Subgroup analysis revealed this association was only significant in APOE ε4 non-carriers.
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>Discussion
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>This cross-sectional study provides novel evidence for the association of physical activity with blood-based biomarkers of neurodegeneration, and how APOE ε4 presence modifies this relationship.