> Key findings reveal that MPs/NPs enter the body via ingestion, inhalation, and dermal contact, translocating across biological barriers to induce DNA damage and oxidative stress through reactive oxygen species overproduction. They disrupt intestinal barrier function by reducing tight junction proteins, trigger chronic inflammation via pro-inflammatory cytokines, and cause gut microbiota dysbiosis. Additionally, MPs/NPs act as “Trojan horses”, adsorbing toxicants (e.g., bisphenol A) and pathogens, which exacerbate cytotoxicity and activate carcinogenic pathways.
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From the article:
> Key findings reveal that MPs/NPs enter the body via ingestion, inhalation, and dermal contact, translocating across biological barriers to induce DNA damage and oxidative stress through reactive oxygen species overproduction. They disrupt intestinal barrier function by reducing tight junction proteins, trigger chronic inflammation via pro-inflammatory cytokines, and cause gut microbiota dysbiosis. Additionally, MPs/NPs act as “Trojan horses”, adsorbing toxicants (e.g., bisphenol A) and pathogens, which exacerbate cytotoxicity and activate carcinogenic pathways.