Ein paar Dutzend Menschen auf der Welt haben eine seltene genetische Mutation, die ihnen die Fähigkeit gibt, alle Viren abzuwehren. Ein von dieser Inspiration inspiriertes mRNA-basiertes Antiviral verhindert die Virusreplikation bei Hamstern/ Mäusen, und Wissenschaftler müssen noch ein Virus gefunden, das seine Abwehrkräfte in der Zellkultur durchbrechen kann.

I’ve linked to the press release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:

**An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections** in vitro and in vivo

https://www.science.org/doi/10.1126/scitranslmed.adx5758

From the linked article:

One Universal Antiviral to Rule Them All?

Taking inspiration from a rare mutation that makes people impervious to viral diseases, a Columbia researcher is developing a therapy that could bestow this superpower on the rest of us

**For a few dozen people in the world, the downside of living with a rare immune condition comes with a surprising superpower—the ability to fight off all viruses**.

Columbia immunologist Dusan Bogunovic discovered the individuals’ antiviral powers about 15 years ago, soon after he identified the genetic mutation that causes the condition.

In his latest study, published Aug. 13 in Science Translational Medicine(link is external and opens in a new window), Bogunovic and his team report that an experimental therapy they’ve developed temporarily gives recipients (hamsters and mice, so far) the same antiviral superpower as people with ISG15 deficiency. When administered prophylactically into the animals‘ lungs via a nasal drip, **the therapy prevented viral replication of influenza and SARS-CoV-2 viruses and lessened disease severity.**

**In cell culture, “we have yet to find a virus that can break through the therapy’s defenses,” Bogunovic says**.