Neue mRNA-basierte Impfstoff gegen Magenkrebs führten bei allen behandelten Mäusen zu Tumorregression und Ausrottung. Am umfangreichsten ist, dass der Impfstoff eine beeindruckende Wirksamkeit der Antitumor gegen die Peritonealmetastasierung zeigt, die historisch gesehen sehr schwierig zu behandeln war.

I’ve linked to the press release in the post above. In this comment, for those interested, here’s the link to the peer reviewed journal article:

https://link.springer.com/article/10.1007/s10120-025-01640-8

From the linked article:

The future of ‘personalized’ cancer treatment: Antitumor mRNA-based vaccines

Researchers investigate the potential of mRNA vaccines against gastric cancer metastasis

Once the vaccine was synthesized, they proceeded to test it, both alone and in combination with anti-PD-1 therapy, in various mouse models. The results were very promising—firstly, the vaccine induced a higher frequency of neoAg-specific cytotoxic T cells in mice than a similar neoAg-dendritic cell-based vaccine. On testing in a therapeutic setting, **mRNA-based vaccination led to tumor regression and eradication in all treated mice**, and this effect was enhanced in combination with anti-PD-1 therapy.

**Most promisingly, the vaccine shows impressive antitumor efficacy against peritoneal metastasis, which has historically been very challenging to treat**. The vaccine on its own showed a protective effect in mice that were inoculated intraperitoneally with YTN16 cells. In combination with anti-PD-1 therapy, it was shown to reduce tumor growth even in mice with already established peritoneal metastases.

I’m starting to wonder if there are going to be multiple mRNA vaccine-related Nobel prizes awarded. At least from the layman’s perspective, it seems highly transformative, including to applications well beyond viruses.