Eine neue Studie an Nagetieren zeigt, dass die psychedelische Verbindung 5-MeO-DMT einen Rezeptor mit einem nicht halluzinogenen Analogon, TBG, teilt. TBG aktiviert jedoch nicht die gleichen Gene wie DMT, obwohl es immer noch die Neuroplastizität fördert. Dies deutet darauf hin, dass therapeutische und halluzinogene Wirkungen getrennt werden können.
https://www.ucdavis.edu/news/psychedelics-and-non-hallucinogenic-analogs-work-through-same-receptor-point
7 Kommentare
Link to paper (Nature Neuroscience): [https://www.nature.com/articles/s41593-025-02021-1](https://www.nature.com/articles/s41593-025-02021-1)
Does this mean that people with schizophrenia/psychosis could safely use a substance like this? Assuming there’s no dangerous side effects and so on.
the effects can be separated but you might not get all of the beneficial effects then. neurogenesis being the foundation of the “healing” or “recovery” that happens with psychedelics is not proven to be the case. it could be just as likely (more so in my opinion) that the *insight* gained is more beneficial and leads to cascading positive effects on brain health that goes beyond just building new neurons.
there’s a number of things we do that builds new neurons but isn’t as fundamentally life-changing like a single psychedelic experience can be. there’s more going on, and neurology may not ever have the tools to entirely figure it out alone.
i suppose having this substance as a sort of “control” will come to prove this or disprove this theory with time. i’m curious to see where this research is in a decade.
When they treat alcoholics with psychedelics, they often have flowers sitting out during the session. The subjective experience of watching the flower whither and die as they think of drinking and then grow and flourish as they think of living a sober life is hugely beneficial. People are too quick to try and get rid of the actual psychedelic effects and write them off as not being a necessary component.
This is exactly what people want to do when studying lsd, but couldn’t due to schedule 1 status. Separate the trippy part and retain the neuro benefits.
So we are taking all the fun and experience out of the equation.
My counter argument proposal: the psychedelic effects are effective at causing a “dissolution of the self”. This dissolution of the self then allows people not to suffer anymore for a bit since there is no “self” to suffer results in your brain. Additionally this removal of the internal self makes you feel that you are connected to everything and/or that everything is empty and devoid of importance. Thus to reduce certain psychedelic effects is to decrease effectiveness for certain mentally imposed harm.