Die Blockierung eines neuronalen Rezeptors könnte den Alkoholkonsum verringern: Forscher fanden in Tierversuchen heraus, dass ein neues Therapeutikum, das auf den Kappa-Opioidrezeptor (LY2444296) im Gehirn abzielt, die Alkoholabhängigkeit verringern kann

> For their study, Martin-Fardon and Flores-Ramirez sought to find out whether orally administering LY2444296 could decrease alcohol consumption in rats that formed alcohol dependency. The aim was to mitigate withdrawal symptoms, which would hypothetically lead to reduced alcohol intake. Once rats received LY2444296 at doses as low as 3 mg per kg following 8 hours of abstinence—when acute withdrawal symptoms typically start— withdrawal signs and alcohol consumption tapered down significantly. The researchers also determined that LY2444296 may be innocuous, as it had neither a positive nor negative effect on rats without alcohol dependency.

Paper: [LY2444296, a κ-opioid receptor antagonist, selectively reduces alcohol drinking in male and female Wistar rats with a history of alcohol dependence | Scientific Reports](https://www.nature.com/articles/s41598-024-56500-9)