Eine einzelne Dosis Psilocybin kann zu dauerhaften Veränderungen in den Lebenswerten eines Menschen führen, wie etwa zu einer gesteigerten Wertschätzung für das Leben und einer größeren Selbstakzeptanz. Diese dauerhaften Veränderungen scheinen auf spezifische akute Wirkungen der Droge zurückzuführen zu sein, insbesondere auf Gefühle tiefer Einigkeit und Euphorie.
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A single dose of psilocybin can lead to lasting shifts in a person’s life values, such as an increased appreciation for life and greater self-acceptance. These lasting changes appear to be driven by specific acute effects of the drug, particularly feelings of profound unity and euphoria. The findings were recently published in the Journal of Psychopharmacology.
Psilocybin is the active chemical found in certain species of mushrooms. It is a classic psychedelic drug that temporarily alters human perception and mood. The chemical works largely by binding to specific serotonin receptors in the brain. Serotonin is a chemical messenger involved in many neural functions, including mood regulation.
Researchers have conducted early clinical trials to test whether this chemical can help treat mental health conditions. Some trials have explored its use for major depressive disorder, anxiety associated with advanced cancers, and alcohol use disorder. Early trial results indicate that the drug might facilitate changes in beliefs and subjective well-being. These outcomes have sparked renewed interest in psychedelic therapies.
Researchers suspect that these positive psychological shifts rely heavily on the quality of a person’s initial experience while under the influence of the drug. People who report feelings of spiritual connection or a sense of ego dissolution often show the greatest long-term psychological changes. Ego dissolution refers to a temporary loss of one’s sense of self and a feeling of deep connection with the surrounding world. This temporary state may create opportunities for emotional healing.
For those interested, here’s the link to the peer reviewed journal article:
https://journals.sagepub.com/doi/10.1177/02698811251408769
I must have done it wrong. All I got was anxiety.
So often I feel like we have the knowledge and tools to make life so much better for all of us. Yet we would rather complain than behavior change. It’s obviously way more complex than that. But in some ways it is that simple
> double-blind, randomized, placebo-controlled trial. They recruited eighty-nine healthy adult participants who had no current or past psychiatric disorders. Each participant was assigned to receive either twenty-five milligrams of psilocybin, ten milligrams of psilocybin, or an inactive placebo.
> The study results revealed that psilocybin did not alter basic personality traits or psychiatric symptoms in this specific group. The lack of change in psychological symptoms was anticipated, as the volunteers were healthy individuals without psychiatric diagnoses. Personality traits are generally stable over a lifespan, making them difficult to alter with a single experimental intervention.
> did observe distinct shifts in personal values among those who received either dose of the active drug compared to the placebo group
> These life value shifts remained present at both the one-week and twelve-week follow-up points
> The participants who experienced the highest degrees of oceanic boundlessness were the ones who reported the greatest positive shifts in their life values
> To a lesser degree, some participants who experienced auditory alterations while on the drug also showed short-term increases in social and planetary concerns.
(the above is very interesting to me)
> The team found no statistical differences in cognitive flexibility between the psilocybin groups and the placebo group.
> The measurement tool may also lack the sensitivity needed to capture subtle psychological shifts
> The use of an inactive placebo means that participants likely knew whether they had received the psychoactive drug or not. These subjective effects can lead to a phenomenon known as functional unblinding
(How do we get around this problem for people who havs experience with the drug, thus should have some idea about its effects?)
> Many of the volunteers in this trial also had prior experience with psychedelic substances in their personal lives. Their previous use might have shaped their expectations and their baseline personality traits.
The participants were aware of whether they received the placebo or not, which seems to be a very important limitation of the study
Mushrooms made me spiritual, I never have been in the past. Truly life changing