Pythonblut könnte das Geheimnis einer gesunden Gewichtsabnahme bergen und neue Therapien zur Gewichtsabnahme ermöglichen, die das Sättigungsgefühl fördern, ohne die Übelkeit und den Muskelschwund, die mit bestehenden Medikamenten einhergehen können
https://www.colorado.edu/today/2026/03/19/python-blood-could-hold-secret-healthy-weight-loss
10 Kommentare
>CU Boulder researchers have discovered an appetite-suppressing compound in python blood that helps the snakes consume enormous meals and go months without eating yet remain metabolically healthy.
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>The research, a collaboration with scientists at Stanford Medicine and Baylor universities, could inform new weight loss therapies that promote satiety without the nausea and muscle loss that can come with existing drugs.
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>“This is a perfect example of nature-inspired biology,” said senior author Leslie Leinwand, a distinguished professor of Molecular, Cellular and Developmental Biology who has been studying pythons in her lab for two decades. “You look at extraordinary animals that can do things that you and I and other mammals can’t do, and you try to harness that for therapeutic interventions
>For the new study, the team measured blood samples from ball pythons and Burmese pythons, fed once every 28 days, immediately after they ate a meal.
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>In all, they found 208 metabolites that increased significantly after the pythons ate. One molecule, called para-tyramine-O-sulfate (pTOS) soared 1,000-fold.
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>Further studies, done with Baylor University researchers, showed that when they gave high doses of pTOS to obese or lean mice, it acted on the hypothalamus, the appetite center of the brain, prompting weight loss without causing gastrointestinal problems, muscle loss or declines in energy.
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>The study found that pTOS, which is produced by the snake’s gut bacteria, is not present in mice naturally. It is present in human urine at low levels and does increase somewhat after a meal.
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>But because most research is done in mice or rats, pTOS has been overlooked.
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>“We’ve basically discovered an appetite suppressant that works in mice without some of the side-effects that GLP-1 drugs have,” said Leinwand, referring to drugs like Ozempic and Wegovy, which act on the hormone glucagon-like petide-1 (GLP-1).
[Python metabolomics uncovers a conserved postprandial metabolite and gut–brain feeding pathway | Nature Metabolism](https://www.nature.com/articles/s42255-026-01485-0)
The strongest detail here is that „One molecule, called para-tyramine-O-sulfate (pTOS) soared 1,000-fold.“ That is the kind of signal that makes the python angle feel more than just a catchy headline.
People will do anything instead of exercise and not eating crap.
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Eat cold potatoes for the most satiating food most have access to and you can get in a calorie deficit without feeling hungry all the time.
For those of you who are being condescending towards people that turn to these drugs instead of dieting and exercising, please consider that obesity and overeating is not simply derived from lack of discipline. Obesity creates robust mechanisms in metabolism and in the gut microbiome that solidify bad eating behaviours. It’s works more like a chemical addiction than anything else.
Also consider that some people don’t have the opportunity to eat healthy food consistently. It’s usually more expensive and/or time consuming to purchase and cook. Some are simply genetically vulnerable to these conditions. Education systems sparsely teach truly good skills for dieting and healthy eating. Sometimes drugs and medical interventions are ideal considering how overburdened the average individual is nowadays.
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Or societies could start forming healthy relationships around food again? That would mean from the top down, starting with multinational food conglomerates, on down to the local levels of society.
Food is energy, and its used as a soothing and coping mechanism instead of its intended purpose to fuel a thriving body.
I’m more upset by the fact that we’re chasing a „weight loss solution“. We already know the answer is *eating less*.
Why are we continuing to extract reptile hormones?
It is also produced in humans, finding it in urine is a marker for depression but not strongly enough correlated for a clinical diagnosis.
Not sure this will go anywhere, it’s not a new discovery it was researched in the 70’s already.