Bei Super-Agern, also Menschen mit außergewöhnlicher geistiger Klarheit, ist die Wahrscheinlichkeit, dass sie Träger des Alzheimer-assoziierten APOE-ε4-Gens sind, um 68 % geringer, und die Wahrscheinlichkeit, dass sie dasselbe Gen tragen, ist um 19 % geringer als bei kognitiv normalen Altersgenossen ab 80 Jahren
Study finds so-called super agers tend to have at least two key genetic advantages
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>A comparatively large study reported Jan. 16 in Alzheimer’s & Dementia, The Journal of the Alzheimer’s Association, led by researchers at Vanderbilt Health, measures the frequency of APOE-ε4 and APOE-ε2 in so-called super agers — people ages 80 or older whose cognitive function is comparable to people 20 or 30 years younger.
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>Super agers were 68% less likely to harbor the gene nobody wants, APOE-ε4, compared to individuals with AD dementia in the same 80+ age group.
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>Most notably, super agers were 19% less likely to harbor APOE-ε4 than were cognitively normal participants in the same age group.
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>“This was our most striking finding — although all adults who reach the age of 80 without receiving a diagnosis of clinical dementia exhibit exceptional aging, our study suggests that the super-ager phenotype can be used to identify a particularly exceptional group of oldest-old adults with a reduced genetic risk for Alzheimer’s disease,” said Leslie Gaynor, PhD, assistant professor of Medicine in the Division of Geriatric Medicine, who led the study with Alaina Durant, BS, statistical genetic analyst in the Vanderbilt Memory and Alzheimer’s Center.
> Super-ager status was defined in part as people ages 80+ whose memory performance was above the average scored among cognitively normal participants ages 50 to 64. The study included multiple race/ethnicity groups, including 1,412 non-Hispanic white super agers, 211 non-Hispanic Black super agers, 8,829 participants with AD dementia, and 7,628 cognitively normal controls. APOE-ε4 frequency worldwide is 13.7%; in the study it was 43.9%.
[Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers – Durant – 2026 – Alzheimer’s & Dementia – Wiley Online Library](https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71024)
If you do carry this variant then you should be doing everything you can to limit the chance of getting Alzheimers or limit it’s impact. So that’s exercise, good diet and sleep. Exercise and sleep will help clear out the crap from the brain, which is particularly important since that gene impairs the clearance of amyloid from the brain. And it’s not just the general exercise is good, but exercise is the best thing you can do.
>For the AD portrait, the top three scoring treatments for reversing AD expression with little effect on exacerbating AD expression were for exercise.
[https://www.nature.com/articles/s41598-022-22179-z#Sec2](https://www.nature.com/articles/s41598-022-22179-z#Sec2)
Also everyone get’s their hopes up with animal experiments, but the reality is we don’t really know the cause of dementia for sure, so it might be that the treatment isn’t even treating the same kind dementia in humans. Which explains why treatments that work in animals never seem to help with humans.