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33 Kommentare
The perfect metaphor for the pharmaceutical industry and the state of modern medicine.
>An Oxford review examining 37 studies involving more than 9,300 people found that on average, users gained around a pound a month after quitting.
Yes, because, as ever, big pharma is only interested in treating the $ymptom not the condition.
Surely the GLP1 debate actually proves one thing.
That for many, weight gain is hormonal, not a willpower issue.
I’d have thought that restricting food intake for a reasonable amount of time would change patients’ habits. The fact that it apparently doesn’t suggests we still don’t understand (or are unable to treat) the root cause of obesity, only the symptoms.
I’ve been reading an interesting book over Christmas called „Ultra processed people“. It talks about how modern obesity is not due to fats, or carbs, but actually ultra processing of our modern diets. The ultra processing tricks our brains into over consumption, and allows us to consume quantities of sugar that we would never tolerate otherwise (try eating 30g of sugar in tablespoons). Ultra processed foods also have addictive like qualities, and some people do have genetic components where their brains don’t tell them to stop. The drug is a fix for the symptoms of the current food industry, but the food itself is the problem that needs fixing.
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Very lucky to have used these drugs and it completely changed my eating habits and I didn’t gain weight back after coming off them
It’s a shame it can’t be that way for everyone
Edit : here’s what I think is going to happen to a lot of people
These drugs cause extreme calorie deficits
Big deficits without exercise, mainly resistance training, cause a large % of muscle to be lost as weight
So people lose lots of muscle and fat, making them less metabolically active.
They cone off the drugs and gain the weight back
The cycle repeats
It must be remembered that the currently approved drugs still represent an early generation of these medicines and a considerable amount of investment has gone into development of successors. There are about a dozen follow-up candidates in clinical development that are aiming to address the issues of rebound weight gain and also to try and focus the weight loss more specifically on fat. So I would take care about getting too outraged when reading articles about how „awfully wobbly“ these Wright Brothers planes are.
Chronic medical conditions require ongoing medication – I keep seeing articles saying basically this and it’s really annoying. I’ve got multiple chronic health issues that require that I take medication for the rest of my life – I cannot see the difference between my kidney medication and this.
Imagine the same headline, but the topic is type one diabetics and insulin. Absolutely absurd article.
„Fat jabs“ Typical UK and from a news source too. Although „News“ is being generous.
They provide an instant ability for people who previously struggled to manage a calorie deficit. Although that already varies for some. I’m happy to say I’m on Wegovy. I had a much lower starting BMI than some who use it but the effects on my sleep, my back and my ability to be the active parent I want to be were clear.
I’ve lost about 15KG (about 2 stone 3lbs) since I started about 80 days ago. But actually the biggest changes I’ve achieved have been lifestyle and eating habits. One’s I’ve made before but without the meds but this time as part of a more sustainable look at life. Before the diets were based around eating what this or that diet said I should. No carbs, lots of soup, this fad or that. This time I’m actually looking at changing how I eat not always what. Understanding that you can eat carbs and chocolate and still lose weight if you factor them in makes the diet more sustainable as you’re not depriving yourself of things you enjoy. A glass of wine on a Friday is fine if you count it.
Treats such as a nice meal out rather than a lazy pizza in the oven, finding high protein diets that scratch that itch. Finding the joy in exercise again.
It’s been more like a reset than taking something that makes me not eat at all. I still feel hunger and still have cravings for custard creams (others don’t, but my response has been more mild). I actually think there’s something to be said for staying on the lowest possible dose that means you still need to think about what and how you’re eating so it is exercising people’s will power still, not just making it so people don’t have to think about what they are eating because they can’t eat much.
I think the medication is excellent but it needs to stop being viewed as a magic fat burning jab and looked at far more holistically, as part of a bigger thing. I hope I’m managing to do this but it shouldn’t be something left or the individual to build in otherwise the journey won’t be sustainable and the chance of bouncing back quickly is really possible.
Most people need to make lifestyle changes alongside any assistance from ozempic and similar substances. Learning to cook from scratch, portion control, cutting down on processed sugar, and some form of regular exercise (doesn’t have to by the gym).
Why is this shocking to people? Generally medications stop working when you don’t take them.
People want a shitty ultra processed diet more than they want a healthy body. I do a lot of exercise each week and when I go shopping, do I see those jam doughnuts, pringles and Toblerone bars, and feel a craving to eat them? Yes. Do I buy them? No.
„Calorie control and regular exercise may need to be taken for life, health experts warn“
Nonsense, they will soon launch a tablet form.
Now they will be taken for life!
The title is misleading. “GLP-1 agonists may need to be taken…” is more accurate but it’s very possible a better hormone may be found to target in the future. We’re in the very early stages of this type of treatment. I have no doubt that in the near future ’fat jabs’ will be replaced by tablets, patches or such like.
Unsurprising really, it’s a chronic condition.
They seem to have a study in rats that has demonstrated a gene therapy that causes the pancreas to release GLP-1, I’m not sure it’s something that I’d be keen on though. Currently the oral versions that are showing good results are what I expect to take over the long term.
Overall I’m just thankful they developed a treatment.
until they become pills, as one already has. These headlines are so poorly written.
Idk how people can argue that this is normal or healthy. Unless you have diabetes or a diagnosed illness, surely there are better ways to overcome your weight problems than paying £300 a month to inject something into your stomach that blocks your appetite for the rest of your LIFE. It’s almost dystopian. The amount of people taking this is wild. Rather than just work on mental health, exercise, healthy eating.
Can’t believe how many people are on these when no one really knows the long term effects 😵💫
Injecting chemicals every day of your life v eating healthier foods. I’d be straight to the greengrocer for a banana.
It’s not always going to be jabs though. Soon it’s going to be pills, and the idea of taking a pill each day isn’t that bad, especially if it provides better health outcomes overall. I’ve been using wegovy (only 0.25mg, I’m very sensitive to it) and it’s definitely helped a lot with reducing sugar binging. If people are given a low dose and it’s affordable with no long term negative side effects I don’t see why this is a bad thing really.
As someone who has lost a significant amount of weight, if I don’t watch what I eat and lead an extremely active lifestyle I will regain all the weight extremely quickly. It’s always going to be a monkey on my back.
It not only took a lot of will power but I have learnt so much about nutrition thay I can eye ball most food and have a pretty decent understanding of how much Protien and calories are in it.
I am absolutely certain that as time goes on it will be proven that Ultra Processed Foods are going to be the main cause of many illnesses and conditions.
It will be interesting to see how this was researched.
A lot of obese people on these dont diet as well. It increases your metabolism and suppresses hunger but how many of those people, after being on those jabs, go back to eating the same stuff that got them there in the first place?
If someone was to use these jabs and then diets from there, are the results the same?
I have a couple of chronic illnesses.
One is cluster migraines. I take a medication that keeps them under control. I know I’m not cured, and will likely need the medication for life (although they started with puberty so we’re hoping menopause improves them)
Another is obesity (and insulin resistance/PCOS) . I’m taking a medication (the „fat jab“) that keeps that under control.
I know it’ll likely be something I need for life.
I’ve not been a strong responder so can still eat well with no supression, and have suffered no negative side effects, so whilst my weight loss has been slower, having to still consider eating to satiate my hunger has likely helped me much more than people who have had a strong response.
I’m pretty lucky that I can atm afford it. There will probably be a time I can’t.
And depsite feeling confident I’ve done everything 8 can to do this the best way it horrible knowing that I might have to stop the medication
But surely there are still cases in which a temporary use of the drug could be helpful? Is there not some possibility that using the drug for a certain amount of time brings people down to a weight at which a lifestyle change becomes easier?
I’m sure there are some overweight people who would like to become more active but are put off because their weight makes everything exhausting. If getting started is the hard part for those people, then does the drug not have some use a kick-starter to get them on their way?
Well yeah, that was obvious from the get-go. If you can’t lose weight without a drug your willpower won’t stop you overeating or whatever once the druge stops
Okay, and?
These jabs are lifesaving for the people that take them.
I been saying this forever. All the stuff you read about how good the jabs are is from pharmaceutical spam bots, clear as day and night. In history there has been hundreds of quick fix or magic tablets for diet and they all work tremendously until they fail. Amphetamines come to mind.
There is no free lunch in this universe. Everything good requires work. Just the way things are. 95% of people taking this jab will never change their lifestyle.
Pharma companies making a killing with another temp fix. You suckers all bought into it
Isn’t this obvious?
These jabs are all GLP-1 hormone mimicking API’s. It works by tricking the body into secreting lots more insulin to tackle excess sugar, and likewise excess insulin provides a negative feedback mechanism to the hunger response.
As a result, people on the jabs who have an overeating problem feel a lot less hungry, and their body is producing more hormones to tackle current weight.
At no point do these instil any dieting discipline. If you come off them, the hormone profile helping you burn through extra sugar in your blood is lowered to normal again, and your hunger response goes back to how it was. The only way to maintain body weight is eat sufficient and no more, with regular light exercise (walking). The only way to lose body weight is to eat under sufficient, with regular moderate exercise.
Dieting isn’t temporary, if you want the weight off, you have to eat that diet regime forever. These drugs help because it speeds up metabolism somewhat, and also hijacks hunger cravings.
Can we log this in the No S Sherlock folder?
Medicine for chronic disease highlights it’s the underlying cause not the outcome that’s the issue?
Once you gain weight, those fat cells don’t go anywhere. They just shrink when you lose weight, ready to refill again. So the solution can’t be making fat people thin, it has to be preventing people from getting fat in the first place. That means a massive drive against child obesity and to stop normalising a „modern western“ diet full of addictive sugar.