Eine neue Studie bringt gängige „Dauerchemikalien“ mit einem höheren Risiko für Lebererkrankungen bei Jugendlichen in Verbindung: PFAS kann die Wahrscheinlichkeit verdreifachen, dass Jugendliche eine metabolisch assoziierte Lebererkrankung (MASLD) entwickeln, die als Fettlebererkrankung bekannt ist.

>The research examined 284 Southern California adolescents and young adults from two USC longitudinal studies. The participants were already at higher metabolic risk because their parents had type 2 diabetes or were overweight. PFAS levels were measured through blood tests, and liver fat was assessed using MRI.
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>Higher blood levels of two common PFAS — perfluorooctanoic acid (PFOA) and perfluoroheptanoic acid (PFHpA) — were linked to a greater likelihood of MASLD. Adolescents with twice as much PFOA in their blood were nearly three times more likely to have MASLD. The risk was even higher for those with a genetic variant (PNPLA3 GG) known to influence liver fat. In young adults, smoking further amplified PFAS-related liver impacts.
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>“These findings suggest that PFAS exposures, genetics and lifestyle factors work together to influence who has greater risk of developing MASLD as a function of your life stage,” said Max Aung, PhD, MPH, assistant professor of population and public health sciences at the Keck School of Medicine. “Understanding gene and environment interactions can help advance precision environmental health for MASLD.”

[Associations between per- and polyfluoroalkyl substances and metabolic dysfunction-associated steatotic liver disease in adolescents and young adults: modifying roles of age, lifestyle factors, and PNPLA3 genotype – ScienceDirect](https://www.sciencedirect.com/science/article/pii/S0013935125025733)